If coadministration of CYP3A4 inhibitors with fentanyl is critical, observe patients for respiratory depression and sedation at Recurrent intervals and consider fentanyl dose adjustments till stable drug effects are obtained.
lumacaftor/ivacaftor will decrease the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
ceritinib will increase the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
isocarboxazid will increase toxicity of fentanyl by Other (see remark). Contraindicated. Comment: Avoid fentanyl in patients who require concomitant administration MAOIs, or within 14 days of stopping an MAOI. Serious and unpredictable potentiation by MAO inhibitors has been reported with opioid analgesics.
Voxelotor raises systemic exposure of delicate CYP3A4 substrates. Stay away from coadministration with sensitive CYP3A4 substrates with a narrow therapeutic index. Consider dose reduction from the sensitive CYP3A4 substrate(s) if not able to stay clear of.
Watch Intently (1)nevirapine will lower the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead on to a reduce in fentanyl plasma concentrations, insufficient efficacy or, maybe, progress of the withdrawal syndrome in a affected person that has produced Bodily dependence to fentanyl.
fentanyl, dexchlorpheniramine. Possibly boosts toxicity on the other by pharmacodynamic synergism. Modify Therapy/Observe Intently. Coadministration of fentanyl with anticholinergics may well raise risk for urinary retention and/or critical constipation, which may bring about paralytic ileus.
fentanyl and buprenorphine buccal both of those improve sedation. Steer clear of or Use Alternate Drug. Limit use to patients for whom substitute treatment options are inadequate
Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants, like alcohol, may possibly result in profound sedation, respiratory depression, coma, and death; reserve concomitant prescribing fentanyl labor for use in patients for whom different treatment options are inadequate; limit dosages and durations to minimum needed; observe patients for signs and symptoms of respiratory depression and sedation
If you need to go to A&E, usually do not generate yourself. Get somebody else to push you or demand an ambulance.
If you should visit a&E, do not travel yourself. Get another person to generate you or demand an ambulance.
fentanyl, brompheniramine. Both increases toxicity in the other by pharmacodynamic synergism. Modify Therapy/Keep an eye on Intently. Coadministration of fentanyl with anticholinergics may raise risk for urinary retention and/or significant constipation, which can bring about paralytic ileus.
Narcotic agonist-analgesic of opiate receptors; inhibits ascending pain pathways, Therefore altering response to pain; boosts pain threshold; generates analgesia, respiratory depression, and sedation
Stay away from or substitute another drug for these medications when attainable. Evaluate for loss of therapeutic effect if medication need to be coadministered. Modify dose In keeping with prescribing information if necessary.